Muscleblind-like 1 activates insulin receptor exon 11 inclusion by enhancing U2AF65 binding and splicing of the upstream intron

Alternative splicing regulates developmentally and tissue-specific gene expression programs, disruption of which have been implicated in numerous diseases. Muscleblind-like 1 (MBNL1) regulates splicing transitions, which are disrupted on loss of MBNL1 function in myotonic dystrophy type 1 (DM1). One...

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Detalles Bibliográficos
Autores principales: Echeverria, Gloria V., Cooper, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919616/
https://www.ncbi.nlm.nih.gov/pubmed/24185704
http://dx.doi.org/10.1093/nar/gkt1020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919616/
https://www.ncbi.nlm.nih.gov/pubmed/24185704
http://dx.doi.org/10.1093/nar/gkt1020

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