Liver-Specific γ-Glutamyl Carboxylase-Deficient Mice Display Bleeding Diathesis and Short Life Span

Vitamin K is a fat-soluble vitamin that plays important roles in blood coagulation and bone metabolism. One of its functions is as a co-factor for γ-glutamyl carboxylase (Ggcx). Conventional knockout of Ggcx causes death shortly after birth in homozygous mice. We created Ggcx-floxed mice by insertin...

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Detalles Bibliográficos
Autores principales: Azuma, Kotaro, Tsukui, Tohru, Ikeda, Kazuhiro, Shiba, Sachiko, Nakagawa, Kimie, Okano, Toshio, Urano, Tomohiko, Horie-Inoue, Kuniko, Ouchi, Yasuyoshi, Ikawa, Masahito, Inoue, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919827/
https://www.ncbi.nlm.nih.gov/pubmed/24520408
http://dx.doi.org/10.1371/journal.pone.0088643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919827/
https://www.ncbi.nlm.nih.gov/pubmed/24520408
http://dx.doi.org/10.1371/journal.pone.0088643

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