A Review of the Evidence that Ochratoxin A Is an Nrf2 Inhibitor: Implications for Nephrotoxicity and Renal Carcinogenicity

Several studies have demonstrated that ochratoxin A (OTA) inhibits the nuclear factor, erythroid 2-like 2 (Nrf2) oxidative stress response pathway. At the cellular level this would attenuate (i) glutathione synthesis; (ii) recycling of oxidised glutathione; (iii) activity of oxidoreductases; and (iv...

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Detalles Bibliográficos
Autores principales: Limonciel, Alice, Jennings, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920267/
https://www.ncbi.nlm.nih.gov/pubmed/24448208
http://dx.doi.org/10.3390/toxins6010371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920267/
https://www.ncbi.nlm.nih.gov/pubmed/24448208
http://dx.doi.org/10.3390/toxins6010371

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