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Src tyrosine kinase signaling antagonizes nuclear localization of FOXO and inhibits its transcription factor activity

Biochemical experiments in mammalian cells have linked Src family kinase activity to the insulin signaling pathway. To explore the physiological link between Src and a central insulin pathway effector, we investigated the effect of different Src signaling levels on the Drosophila transcription facto...

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Detalles Bibliográficos
Autores principales: Bülow, Margret H., Bülow, Torsten R., Hoch, Michael, Pankratz, Michael J., Jünger, Martin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920272/
https://www.ncbi.nlm.nih.gov/pubmed/24513978
http://dx.doi.org/10.1038/srep04048