Aberrant islet unfolded protein response in type 2 diabetes

The endoplasmic reticulum adapts to fluctuations in demand and copes with stress through an adaptive signaling cascade called the unfolded protein response (UPR). Accumulating evidence indicates that the canonical UPR is critical to the survival and function of insulin-producing pancreatic β-cells,...

Descripción completa

Detalles Bibliográficos
Autores principales: Engin, Feyza, Nguyen, Truc, Yermalovich, Alena, Hotamisligil, Gökhan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920274/
https://www.ncbi.nlm.nih.gov/pubmed/24514745
http://dx.doi.org/10.1038/srep04054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920274/
https://www.ncbi.nlm.nih.gov/pubmed/24514745
http://dx.doi.org/10.1038/srep04054

Ejemplares similares