CTCF and ncRNA Regulate the Three-Dimensional Structure of Antigen Receptor Loci to Facilitate V(D)J Recombination

At both the immunoglobulin heavy and kappa light chain loci, there are >100 functional variable (V) genes spread over >2 Mb that must move into close proximity in 3D space to the (D)J genes to create a diverse repertoire of antibodies. Similar events take place at the T cell receptor (TCR) loc...

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Detalles Bibliográficos
Autores principales: Choi, Nancy M., Feeney, Ann J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920468/
https://www.ncbi.nlm.nih.gov/pubmed/24575097
http://dx.doi.org/10.3389/fimmu.2014.00049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920468/
https://www.ncbi.nlm.nih.gov/pubmed/24575097
http://dx.doi.org/10.3389/fimmu.2014.00049

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