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Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid

Cytochrome P450 (CYP) epoxygenases generate bioactive lipid epoxides which can be further metabolized to supposedly less active diols by the soluble epoxide hydrolase (sEH). As the role of epoxides and diols in angiogenesis is unclear, we compared retinal vasculature development in wild-type and sEH...

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Detalles Bibliográficos
Autores principales: Hu, Jiong, Popp, Rüdiger, Frömel, Timo, Ehling, Manuel, Awwad, Khader, Adams, Ralf H., Hammes, Hans-Peter, Fleming, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920554/
https://www.ncbi.nlm.nih.gov/pubmed/24446488
http://dx.doi.org/10.1084/jem.20131494