Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension

Idiopathic pulmonary arterial hypertension (PAH [IPAH]) is an insidious and potentially fatal disease linked to a mutation or reduced expression of bone morphogenetic protein receptor 2 (BMPR2). Because intravascular inflammatory cells are recruited in IPAH pathogenesis, we hypothesized that reduced...

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Detalles Bibliográficos
Autores principales: Sawada, Hirofumi, Saito, Toshie, Nickel, Nils P., Alastalo, Tero-Pekka, Glotzbach, Jason P., Chan, Roshelle, Haghighat, Leila, Fuchs, Gabriele, Januszyk, Michael, Cao, Aiqin, Lai, Ying-Ju, Perez, Vinicio de Jesus, Kim, Yu-Mee, Wang, Lingli, Chen, Pin-I, Spiekerkoetter, Edda, Mitani, Yoshihide, Gurtner, Geoffrey C., Sarnow, Peter, Rabinovitch, Marlene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920564/
https://www.ncbi.nlm.nih.gov/pubmed/24446489
http://dx.doi.org/10.1084/jem.20111741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920564/
https://www.ncbi.nlm.nih.gov/pubmed/24446489
http://dx.doi.org/10.1084/jem.20111741

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