The Proatherogenic Effect of Chronic Nitric Oxide Synthesis Inhibition in ApoE-Null Mice Is Dependent on the Presence of PPARα

Inhibition of endothelial nitric oxide synthase (eNOS) accelerates atherosclerosis in ApoE-null mice by impairing the balance between angiotensin II (AII) and NO. Our previous data suggested a role for PPARα in the deleterious effect of the renin-angiotensin system (RAS). We tested the hypothesis th...

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Detalles Bibliográficos
Autores principales: Vechoropoulos, Michal, Ish-Shalom, Maya, Shaklai, Sigal, Sack, Jessica, Stern, Naftali, Tordjman, Karen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920724/
https://www.ncbi.nlm.nih.gov/pubmed/24587793
http://dx.doi.org/10.1155/2014/124583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920724/
https://www.ncbi.nlm.nih.gov/pubmed/24587793
http://dx.doi.org/10.1155/2014/124583

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