Cargando…
Histone deacetylation of NIS promoter underlies BRAF V600E-promoted NIS silencing in thyroid cancer
The BRAF V600E mutation causes impaired expression of sodium iodide symporter (NIS) and radioiodine refractoriness of thyroid cancer, but the underlying mechanism remains undefined. In this study, we hypothesized that histone deacetylation at the NIS (SLC5A5) promoter was the mechanism. Using the ch...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Bioscientifica Ltd
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920838/ https://www.ncbi.nlm.nih.gov/pubmed/24243688 http://dx.doi.org/10.1530/ERC-13-0399 |