Small molecule sensitization to TRAIL is mediated via nuclear localization, phosphorylation and inhibition of chaperone activity of Hsp27

The small chaperone protein Hsp27 confers resistance to apoptosis, and therefore is an attractive anticancer drug target. We report here a novel mechanism underlying the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitizing activity of the small molecule LY303511, an inactive a...

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Detalles Bibliográficos
Autores principales: Mellier, G, Liu, D, Bellot, G, Lisa Holme, A, Pervaiz, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920951/
https://www.ncbi.nlm.nih.gov/pubmed/24176848
http://dx.doi.org/10.1038/cddis.2013.413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920951/
https://www.ncbi.nlm.nih.gov/pubmed/24176848
http://dx.doi.org/10.1038/cddis.2013.413

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