Constitutive localization of DR4 in lipid rafts is mandatory for TRAIL-induced apoptosis in B-cell hematologic malignancies

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) acts as an apoptosis inducer for cancer cells sparing non-tumor cell targets. However, several phase I/II clinical trials have shown limited benefits of this molecule. In the present work, we investigated whether cell susceptibility to...

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Detalles Bibliográficos
Autores principales: Marconi, M, Ascione, B, Ciarlo, L, Vona, R, Garofalo, T, Sorice, M, Gianni, A M, Locatelli, S L, Carlo-Stella, C, Malorni, W, Matarrese, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920963/
https://www.ncbi.nlm.nih.gov/pubmed/24136227
http://dx.doi.org/10.1038/cddis.2013.389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920963/
https://www.ncbi.nlm.nih.gov/pubmed/24136227
http://dx.doi.org/10.1038/cddis.2013.389

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