Ablation of the Proapoptotic Genes Chop or Ask1 Does Not Prevent or Delay Loss of Visual Function in a P23H Transgenic Mouse Model of Retinitis Pigmentosa

The P23H mutation in rhodopsin (Rho(P23H)) is a prevalent cause of autosomal dominant retinitis pigmentosa. We examined the role of the ER stress proteins, Chop and Ask1, in regulating the death of rod photoreceptors in a mouse line harboring the Rho(P23H) rhodopsin transgene (GHL(+)). We used knock...

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Detalles Bibliográficos
Autores principales: Adekeye, Adeseye, Haeri, Mohammad, Solessio, Eduardo, Knox, Barry E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921110/
https://www.ncbi.nlm.nih.gov/pubmed/24523853
http://dx.doi.org/10.1371/journal.pone.0083871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921110/
https://www.ncbi.nlm.nih.gov/pubmed/24523853
http://dx.doi.org/10.1371/journal.pone.0083871

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