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Acute murine antigen-induced arthritis is not affected by disruption of osteoblastic glucocorticoid signalling

BACKGROUND: The role of endogenous glucocorticoids (GC) in the initiation and maintenance of rheumatoid arthritis (RA) remains unclear. We demonstrated previously that disruption of GC signalling in osteoblasts results in a profound attenuation of K/BxN serum-induced arthritis, a mouse model of RA....

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Detalles Bibliográficos
Autores principales: Spies, Cornelia M, Wiebe, Edgar, Tu, Jinwen, Li, Aiqing, Gaber, Timo, Huscher, Dörte, Seibel, Markus J, Zhou, Hong, Buttgereit, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922092/
https://www.ncbi.nlm.nih.gov/pubmed/24491163
http://dx.doi.org/10.1186/1471-2474-15-31