Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL

Hypoxia and doxorubicin can cause cardiotoxicity and loss of myocardial function. These effects are due, in part, to an induction of apoptosis. Herein we identify the apoptotic pathways activated in H9c2 cells in response to hypoxia (O(2)/N(2)/CO(2), 0.5:94.5:5) and doxorubicin (0.5 μM). Although th...

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Detalles Bibliográficos
Autores principales: Reeve, Janice LV, Szegezdi, Eva, Logue, Susan E, Chonghaile, Tríona Ní, O’Brien, Timothy, Ritter, Thomas, Samali, Afshin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922357/
https://www.ncbi.nlm.nih.gov/pubmed/17635642
http://dx.doi.org/10.1111/j.1582-4934.2007.00042.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922357/
https://www.ncbi.nlm.nih.gov/pubmed/17635642
http://dx.doi.org/10.1111/j.1582-4934.2007.00042.x

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