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Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?
Senescence, the state of irreversible cell-cycle arrest, plays paradoxical albeit important roles in vivo: it protects organisms against cancer but also contributes to age-related loss of tissue function. The DNA damage response (DDR) has a central role in cellular senescence. Not only does it contr...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922784/ https://www.ncbi.nlm.nih.gov/pubmed/24472138 http://dx.doi.org/10.1186/2046-2395-3-1 |