Restricted mean survival time: an alternative to the hazard ratio for the design and analysis of randomized trials with a time-to-event outcome

BACKGROUND: Designs and analyses of clinical trials with a time-to-event outcome almost invariably rely on the hazard ratio to estimate the treatment effect and implicitly, therefore, on the proportional hazards assumption. However, the results of some recent trials indicate that there is no guarant...

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Detalles Bibliográficos
Autores principales: Royston, Patrick, Parmar, Mahesh KB
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922847/
https://www.ncbi.nlm.nih.gov/pubmed/24314264
http://dx.doi.org/10.1186/1471-2288-13-152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922847/
https://www.ncbi.nlm.nih.gov/pubmed/24314264
http://dx.doi.org/10.1186/1471-2288-13-152

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