O-fucosylation of the Notch Ligand mDLL1 by POFUT1 Is Dispensable for Ligand Function

Fucosylation of Epidermal Growth Factor-like (EGF) repeats by protein O-fucosyltransferase 1 (POFUT1 in vertebrates, OFUT1 in Drosophila) is pivotal for NOTCH function. In Drosophila OFUT1 also acts as chaperone for Notch independent from its enzymatic activity. NOTCH ligands are also substrates for...

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Detalles Bibliográficos
Autores principales: Müller, Julia, Rana, Nadia A., Serth, Katrin, Kakuda, Shinako, Haltiwanger, Robert S., Gossler, Achim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922938/
https://www.ncbi.nlm.nih.gov/pubmed/24533113
http://dx.doi.org/10.1371/journal.pone.0088571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922938/
https://www.ncbi.nlm.nih.gov/pubmed/24533113
http://dx.doi.org/10.1371/journal.pone.0088571

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