Suppression of the SOX2 Neural Effector Gene by PRDM1 Promotes Human Germ Cell Fate in Embryonic Stem Cells

The mechanisms of transcriptional regulation underlying human primordial germ cell (PGC) differentiation are largely unknown. The transcriptional repressor Prdm1/Blimp-1 is known to play a critical role in controlling germ cell specification in mice. Here, we show that PRDM1 is expressed in developi...

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Detalles Bibliográficos
Autores principales: Lin, I-Ying, Chiu, Feng-Lan, Yeang, Chen-Hsiang, Chen, Hsin-Fu, Chuang, Ching-Yu, Yang, Shii-Yi, Hou, Pei-Shan, Sintupisut, Nardnisa, Ho, Hong-Nerng, Kuo, Hung-Chih, Lin, Kuo-I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923219/
https://www.ncbi.nlm.nih.gov/pubmed/24527393
http://dx.doi.org/10.1016/j.stemcr.2013.12.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923219/
https://www.ncbi.nlm.nih.gov/pubmed/24527393
http://dx.doi.org/10.1016/j.stemcr.2013.12.009

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