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Synergistic enhancement of NK cell-mediated cytotoxicity by combination of histone deacetylase inhibitor and ionizing radiation

BACKGROUND: The overexpression of histone deacetylase (HDAC) and a subsequent decrease in the acetylation levels of nuclear histones are frequently observed in cancer cells. Generally it was accepted that the deacetylation of histones suppressed expression of the attached genes. Therefore, it has be...

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Detalles Bibliográficos
Autores principales: Son, Cheol-Hun, Keum, Jin-Hee, Yang, Kwangmo, Nam, Jiho, Kim, Mi-Ju, Kim, Sun-Hee, Kang, Chi-Dug, Oh, Sae-Ock, Kim, Chi-Dae, Park, You-Soo, Bae, Jaeho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923253/
https://www.ncbi.nlm.nih.gov/pubmed/24512718
http://dx.doi.org/10.1186/1748-717X-9-49