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A Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes: Regulation by the Constitutive Androstane Receptor

[Image: see text] The modulation of drug metabolism enzyme (DME) expression by therapeutic agents is a central mechanism of drug–drug interaction and should be assessed as early as possible in preclinical drug development. Direct measurement of DME levels is typically achieved by Western blotting, q...

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Detalles Bibliográficos
Autores principales: MacLeod, A. Kenneth, Zang, Tuo, Riches, Zoe, Henderson, Colin J., Wolf, C. Roland, Huang, Jeffrey T.-J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923450/
https://www.ncbi.nlm.nih.gov/pubmed/24303842
http://dx.doi.org/10.1021/pr400897t