A Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes: Regulation by the Constitutive Androstane Receptor

[Image: see text] The modulation of drug metabolism enzyme (DME) expression by therapeutic agents is a central mechanism of drug–drug interaction and should be assessed as early as possible in preclinical drug development. Direct measurement of DME levels is typically achieved by Western blotting, q...

Descripción completa

Detalles Bibliográficos
Autores principales: MacLeod, A. Kenneth, Zang, Tuo, Riches, Zoe, Henderson, Colin J., Wolf, C. Roland, Huang, Jeffrey T.-J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923450/
https://www.ncbi.nlm.nih.gov/pubmed/24303842
http://dx.doi.org/10.1021/pr400897t

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923450/
https://www.ncbi.nlm.nih.gov/pubmed/24303842
http://dx.doi.org/10.1021/pr400897t

Ejemplares similares