Human Gene Variants Linked to Enhanced NLRP3 Activity Limit Intramacrophage Growth of Mycobacterium tuberculosis

Activation of the NLRP3 inflammasome and subsequent generation of interleukin 1β is initiated in macrophages upon recognition of several stimuli. In the present work, we show that gain-of-function gene variants of inflammasome components known to predispose individuals to inflammatory disorders have...

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Detalles Bibliográficos
Autores principales: Eklund, Daniel, Welin, Amanda, Andersson, Henrik, Verma, Deepti, Söderkvist, Peter, Stendahl, Olle, Särndahl, Eva, Lerm, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923544/
https://www.ncbi.nlm.nih.gov/pubmed/24158955
http://dx.doi.org/10.1093/infdis/jit572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923544/
https://www.ncbi.nlm.nih.gov/pubmed/24158955
http://dx.doi.org/10.1093/infdis/jit572

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