Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

T cell receptors (TCRs) are key to antigen-specific immunity and are increasingly being explored as therapeutics, most visibly in cancer immunotherapy. As TCRs typically possess only low-to-moderate affinity for their peptide/MHC (pMHC) ligands, there is a recognized need to develop affinity-enhance...

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Detalles Bibliográficos
Autores principales: Pierce, Brian G., Hellman, Lance M., Hossain, Moushumi, Singh, Nishant K., Vander Kooi, Craig W., Weng, Zhiping, Baker, Brian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923660/
https://www.ncbi.nlm.nih.gov/pubmed/24550723
http://dx.doi.org/10.1371/journal.pcbi.1003478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923660/
https://www.ncbi.nlm.nih.gov/pubmed/24550723
http://dx.doi.org/10.1371/journal.pcbi.1003478

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