A Repurposing Strategy for Hsp90 Inhibitors Demonstrates Their Potency against Filarial Nematodes

Novel drugs are required for the elimination of infections caused by filarial worms, as most commonly used drugs largely target the microfilariae or first stage larvae of these infections. Previous studies, conducted in vitro, have shown that inhibition of Hsp90 kills adult Brugia pahangi. As numero...

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Detalles Bibliográficos
Autores principales: Gillan, Victoria, O'Neill, Kerry, Maitland, Kirsty, Sverdrup, Francis M., Devaney, Eileen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923716/
https://www.ncbi.nlm.nih.gov/pubmed/24551261
http://dx.doi.org/10.1371/journal.pntd.0002699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923716/
https://www.ncbi.nlm.nih.gov/pubmed/24551261
http://dx.doi.org/10.1371/journal.pntd.0002699

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