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The Membrane-Associated Adaptor Protein DOK5 Is Upregulated in Systemic Sclerosis and Associated with IGFBP-5-Induced Fibrosis

Systemic sclerosis (SSc) is characterized by excessive fibrosis of the skin and internal organs due to fibroblast proliferation and excessive production of extracellular matrix (ECM). We have shown that insulin-like growth factor binding protein (IGFBP)-5 plays an important role in the development o...

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Detalles Bibliográficos
Autores principales: Yasuoka, Hidekata, Yamaguchi, Yukie, Feghali-Bostwick, Carol A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923757/
https://www.ncbi.nlm.nih.gov/pubmed/24551065
http://dx.doi.org/10.1371/journal.pone.0087754