The PDE1/5 Inhibitor SCH-51866 Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington’s Disease

Huntington’s disease is a neurodegenerative disorder caused by mutations in the CAG tract of huntingtin. Several studies in HD cellular and rodent systems have identified disturbances in cyclic nucleotide signaling, which might be relevant to pathogenesis and therapeutic intervention. To investigate...

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Detalles Bibliográficos
Autores principales: Beaumont, Vahri, Park, Larry, Rassoulpour, Arash, Dijkman, Ulrike, Heikkinen, Taneli, Lehtimaki, Kimmo, Kontkanen, Outi, Al Nackkash, Rand, Bates, Gillian P., Gleyzes, Melanie, Steidl, Esther, Ramboz, Sylvie, Murphy, Carol, Beconi, Maria G., Dominguez, Celia, Munoz-Sanjuan, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Pathogenic Mechanism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923778/
https://www.ncbi.nlm.nih.gov/pubmed/24558637
http://dx.doi.org/10.1371/currents.hd.3304e87e460b4bb0dc519a29f4deccca

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923778/
https://www.ncbi.nlm.nih.gov/pubmed/24558637
http://dx.doi.org/10.1371/currents.hd.3304e87e460b4bb0dc519a29f4deccca

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