Cargando…

The PDE1/5 Inhibitor SCH-51866 Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington’s Disease

Huntington’s disease is a neurodegenerative disorder caused by mutations in the CAG tract of huntingtin. Several studies in HD cellular and rodent systems have identified disturbances in cyclic nucleotide signaling, which might be relevant to pathogenesis and therapeutic intervention. To investigate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beaumont, Vahri, Park, Larry, Rassoulpour, Arash, Dijkman, Ulrike, Heikkinen, Taneli, Lehtimaki, Kimmo, Kontkanen, Outi, Al Nackkash, Rand, Bates, Gillian P., Gleyzes, Melanie, Steidl, Esther, Ramboz, Sylvie, Murphy, Carol, Beconi, Maria G., Dominguez, Celia, Munoz-Sanjuan, Ignacio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Pathogenic Mechanism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923778/ https://www.ncbi.nlm.nih.gov/pubmed/24558637 http://dx.doi.org/10.1371/currents.hd.3304e87e460b4bb0dc519a29f4deccca

Ejemplares similares

JAK/STAT Signalling in Huntington’s Disease Immune Cells
por: Träger, Ulrike, et al.
Publicado: (2013)

Efficacy of Selective PDE4D Negative Allosteric Modulators in the Object Retrieval Task in Female Cynomolgus Monkeys (Macaca fascicularis)
por: Sutcliffe, Jane S., et al.
Publicado: (2014)

Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease
por: Heikkinen, Taneli, et al.
Publicado: (2012)

Functional studies of intimin in vivo and ex vivo: implications for host specificity and tissue tropism
por: Mundy, Rosanna, et al.
Publicado: (2007)

The outer membrane secretin PilQ from Neisseria meningitidis binds DNA
por: Assalkhou, Reza, et al.
Publicado: (2007)

TccP2-mediated subversion of actin dynamics by EPEC 2 – a distinct evolutionary lineage of enteropathogenic Escherichia coli
por: Whale, Andrew D., et al.
Publicado: (2007)

Strain-dependent induction of epithelial cell oncosis by Campylobacter jejuni is correlated with invasion ability and is independent of cytolethal distending toxin
por: Kalischuk, Lisa D., et al.
Publicado: (2007)

Expression of the Helicobacter pylori adhesin SabA is controlled via phase variation and the ArsRS signal transduction system
por: Goodwin, Andrew C., et al.
Publicado: (2008)

Identification of a signalling molecule involved in bacterial intergeneric communication
por: Xie, Hua, et al.
Publicado: (2007)

M protein from Streptococcus pyogenes induces tissue factor expression and pro-coagulant activity in human monocytes
por: Påhlman, Lisa I., et al.
Publicado: (2007)

Identification of the Staphylococcus aureus MSCRAMM clumping factor B (ClfB) binding site in the αC-domain of human fibrinogen
por: Walsh, Evelyn J., et al.
Publicado: (2008)

Molecular epidemiology of meningococcal disease in England and Wales 1975–1995, before the introduction of serogroup C conjugate vaccines
por: Russell, Joanne E., et al.
Publicado: (2008)

The expanded CAG repeat in the huntingtin gene as target for therapeutic RNA modulation throughout the HD mouse brain
por: Datson, Nicole A., et al.
Publicado: (2017)

Rapid and robust patterns of spontaneous locomotor deficits in mouse models of Huntington’s disease
por: Heikkinen, Taneli, et al.
Publicado: (2020)

The MACPF/CDC family of pore-forming toxins
por: Rosado, Carlos J, et al.
Publicado: (2008)

BgaA acts as an adhesin to mediate attachment of some pneumococcal strains to human epithelial cells
por: Limoli, Dominique H., et al.
Publicado: (2011)

Contribution of the PhoP/Q regulon to survival and replication of Salmonella enterica serovar Typhimurium in macrophages
por: Thompson, Jessica A., et al.
Publicado: (2011)

Interaction of Bacteroides fragilis and Bacteroides thetaiotaomicron with the kallikrein–kinin system
por: Murphy, Elizabeth C., et al.
Publicado: (2011)

Differences in Salmonella enterica serovar Typhimurium strain invasiveness are associated with heterogeneity in SPI-1 gene expression
por: Clark, Leann, et al.
Publicado: (2011)

Cell-surface nucleolin is sequestered into EPEC microcolonies and may play a role during infection
por: Dean, Paul, et al.
Publicado: (2011)

Roles of the spiA gene from Salmonella enteritidis in biofilm formation and virulence
por: Dong, Hongyan, et al.
Publicado: (2011)

Distribution of espM and espT among enteropathogenic and enterohaemorrhagic Escherichia coli
por: Arbeloa, Ana, et al.
Publicado: (2009)

Identification of virulence determinants of Mycobacterium avium that impact on the ability to resist host killing mechanisms
por: Li, Yong-jun, et al.
Publicado: (2010)

Variation of the factor H-binding protein of Neisseria meningitidis
por: Brehony, Carina, et al.
Publicado: (2009)

Warmer temperatures reduce the vectorial capacity of malaria mosquitoes
por: Paaijmans, Krijn P., et al.
Publicado: (2012)

Influence of the combination and phase variation status of the haemoglobin receptors HmbR and HpuAB on meningococcal virulence
por: Tauseef, Isfahan, et al.
Publicado: (2011)

Role of sialidase in glycoprotein utilization by Tannerella forsythia
por: Roy, Sumita, et al.
Publicado: (2011)

Evolution of the capsular gene locus of Streptococcus pneumoniae serogroup 6
por: Bratcher, P. E., et al.
Publicado: (2011)

The enteropathogenic Escherichia coli effector NleH inhibits apoptosis induced by Clostridium difficile toxin B
por: Robinson, Keith S., et al.
Publicado: (2010)

Role of vimA in cell surface biogenesis in Porphyromonas gingivalis
por: Osbourne, Devon O., et al.
Publicado: (2010)

Two regulatory elements required for enhancing ospA expression in Borrelia burgdorferi grown in vitro but repressing its expression during mammalian infection
por: Xu, Qilong, et al.
Publicado: (2010)

Biofilm formation is not required for early-phase transmission of Yersinia pestis
por: Vetter, Sara M., et al.
Publicado: (2010)

Reduced synthesis of the Ybt siderophore or production of aberrant Ybt-like molecules activates transcription of yersiniabactin genes in Yersinia pestis
por: Miller, M. Clarke, et al.
Publicado: (2010)

Role of Vibrio polysaccharide (vps) genes in VPS production, biofilm formation and Vibrio cholerae pathogenesis
por: Fong, Jiunn C. N., et al.
Publicado: (2010)

Mycobacterium tuberculosis protein kinase K confers survival advantage during early infection in mice and regulates growth in culture and during persistent infection: implications for immune modulation
por: Malhotra, Vandana, et al.
Publicado: (2010)

Interaction of Rickettsia felis with histone H2B facilitates the infection of a tick cell line
por: Thepparit, Chutima, et al.
Publicado: (2010)

Secretion of the chlamydial virulence factor CPAF requires the Sec-dependent pathway
por: Chen, Ding, et al.
Publicado: (2010)

regT can modulate gingipain activity and response to oxidative stress in Porphyromonas gingivalis
por: Vanterpool, E., et al.
Publicado: (2010)

An insert in the covS gene distinguishes a pharyngeal and a blood isolate of Streptococcus pyogenes found in the same individual
por: Garcia, Alan F., et al.
Publicado: (2010)

Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains
por: Cugini, Carla, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_1d378hs0s5g7qbvk9kq22o2k7f