The Development and Survival but Not Function of Follicular B Cells Is Dependent on IL-7Rα Tyr449 Signaling

IL-7 is a critical cytokine for lymphocyte development. Recent work has highlighted critical roles for IL-7 signaling in mature T cell homeostasis and function, but its role in B cells is less well characterized. Using a knock-in mouse possessing a Tyr to Phe mutation at position 449 (IL-7Rα(449F/44...

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Detalles Bibliográficos
Autores principales: Patton, Daniel T., Plumb, Adam W., Redpath, Stephen A., Osborne, Lisa C., Perona-Wright, Georgia, Abraham, Ninan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923819/
https://www.ncbi.nlm.nih.gov/pubmed/24551160
http://dx.doi.org/10.1371/journal.pone.0088771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923819/
https://www.ncbi.nlm.nih.gov/pubmed/24551160
http://dx.doi.org/10.1371/journal.pone.0088771

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