Pharmacological rescue of Ras signaling, GluA1-dependent synaptic plasticity, and learning deficits in a fragile X model

Fragile X syndrome, caused by the loss of Fmr1 gene function, is the most common form of inherited mental retardation, with no effective treatment. Using a tractable animal model, we investigated mechanisms of action of a few FDA-approved psychoactive drugs that modestly benefit the cognitive perfor...

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Detalles Bibliográficos
Autores principales: Lim, Chae-Seok, Hoang, Elizabeth T., Viar, Kenneth E., Stornetta, Ruth L., Scott, Michael M., Zhu, J. Julius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923969/
https://www.ncbi.nlm.nih.gov/pubmed/24493647
http://dx.doi.org/10.1101/gad.232470.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923969/
https://www.ncbi.nlm.nih.gov/pubmed/24493647
http://dx.doi.org/10.1101/gad.232470.113

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