A Mechanism for Actin Filament Severing by Malaria Parasite Actin Depolymerizing Factor 1 via a Low Affinity Binding Interface

Actin depolymerizing factor (ADF)/cofilins are essential regulators of actin turnover in eukaryotic cells. These multifunctional proteins facilitate both stabilization and severing of filamentous (F)-actin in a concentration-dependent manner. At high concentrations ADF/cofilins bind stably to F-acti...

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Detalles Bibliográficos
Autores principales: Wong, Wilson, Webb, Andrew I., Olshina, Maya A., Infusini, Giuseppe, Tan, Yan Hong, Hanssen, Eric, Catimel, Bruno, Suarez, Cristian, Condron, Melanie, Angrisano, Fiona, NebI, Thomas, Kovar, David R., Baum, Jake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924271/
https://www.ncbi.nlm.nih.gov/pubmed/24371134
http://dx.doi.org/10.1074/jbc.M113.523365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924271/
https://www.ncbi.nlm.nih.gov/pubmed/24371134
http://dx.doi.org/10.1074/jbc.M113.523365

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