Transmission of Stability Information through the N-domain of Tropomyosin Is Interrupted by a Stabilizing Mutation (A109L) in the Hydrophobic Core of the Stability Control Region (Residues 97–118)

Tropomyosin (Tm) is an actin-binding, thin filament, two-stranded α-helical coiled-coil critical for muscle contraction and cytoskeletal function. We made the first identification of a stability control region (SCR), residues 97–118, in the Tm sequence that controls overall protein stability but is...

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Detalles Bibliográficos
Autores principales: Kirwan, J. Paul, Hodges, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924298/
https://www.ncbi.nlm.nih.gov/pubmed/24362038
http://dx.doi.org/10.1074/jbc.M113.507236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924298/
https://www.ncbi.nlm.nih.gov/pubmed/24362038
http://dx.doi.org/10.1074/jbc.M113.507236

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