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Probabilistic alignment leads to improved accuracy and read coverage for bisulfite sequencing data
BACKGROUND: DNA methylation has been linked to many important biological phenomena. Researchers have recently begun to sequence bisulfite treated DNA to determine its pattern of methylation. However, sequencing reads from bisulfite-converted DNA can vary significantly from the reference genome becau...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924334/ https://www.ncbi.nlm.nih.gov/pubmed/24261665 http://dx.doi.org/10.1186/1471-2105-14-337 |