Knockdown of autophagy-related protein 5, ATG5, decreases oxidative stress and has an opposing effect on camptothecin-induced cytotoxicity in osteosarcoma cells

BACKGROUND: Autophagy induction can increase or decrease anticancer drug efficacy. Anticancer drug-induced autophagy induction is poorly characterized in osteosarcoma (OS). In this study, we investigated the impact of autophagy inhibition on camptothecin (CPT)-induced cytotoxicity in OS. METHODS: Au...

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Detalles Bibliográficos
Autores principales: Hollomon, Mario G, Gordon, Nancy, Santiago-O’Farrill, Janice M, Kleinerman, Eugenie S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924338/
https://www.ncbi.nlm.nih.gov/pubmed/24160177
http://dx.doi.org/10.1186/1471-2407-13-500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924338/
https://www.ncbi.nlm.nih.gov/pubmed/24160177
http://dx.doi.org/10.1186/1471-2407-13-500

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