Common Handling Procedures Conducted in Preclinical Safety Studies Result in Minimal Hepatic Gene Expression Changes in Sprague-Dawley Rats

Gene expression profiling is a tool to gain mechanistic understanding of adverse effects in response to compound exposure. However, little is known about how the common handling procedures of experimental animals during a preclinical study alter baseline gene expression. We report gene expression ch...

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Detalles Bibliográficos
Autores principales: He, Yudong D., Karbowski, Christine M., Werner, Jon, Everds, Nancy, Di Palma, Chris, Chen, Yuan, Higgins-Garn, Marnie, Tran, Sandra, Afshari, Cynthia A., Hamadeh, Hisham K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925150/
https://www.ncbi.nlm.nih.gov/pubmed/24551150
http://dx.doi.org/10.1371/journal.pone.0088750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925150/
https://www.ncbi.nlm.nih.gov/pubmed/24551150
http://dx.doi.org/10.1371/journal.pone.0088750

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