Promoter Hypermethylation of KLF4 Inactivates Its Tumor Suppressor Function in Cervical Carcinogenesis

OBJECTIVE: The KLF4 gene has been shown to be inactivated in cervical carcinogenesis as a tumor suppressor. However, the mechanism of KLF4 silencing in cervical carcinomas has not yet been identified. DNA methylation plays a key role in stable suppression of gene expression. METHODS: The methylation...

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Detalles Bibliográficos
Autores principales: Yang, Wen-Ting, Zheng, Peng-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925171/
https://www.ncbi.nlm.nih.gov/pubmed/24551169
http://dx.doi.org/10.1371/journal.pone.0088827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925171/
https://www.ncbi.nlm.nih.gov/pubmed/24551169
http://dx.doi.org/10.1371/journal.pone.0088827

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