Photo-Activated Psoralen Binds the ErbB2 Catalytic Kinase Domain, Blocking ErbB2 Signaling and Triggering Tumor Cell Apoptosis

Photo-activation of psoralen with UVA irradiation, referred to as PUVA, is used in the treatment of proliferative skin disorders. The anti-proliferative effects of PUVA have been largely attributed to psoralen intercalation of DNA, which upon UV treatment, triggers the formation of interstrand DNA c...

Descripción completa

Detalles Bibliográficos
Autores principales: Xia, Wenle, Gooden, David, Liu, Leihua, Zhao, Sumin, Soderblom, Erik J., Toone, Eric J., Beyer, Wayne F., Walder, Harold, Spector, Neil L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925176/
https://www.ncbi.nlm.nih.gov/pubmed/24551203
http://dx.doi.org/10.1371/journal.pone.0088983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925176/
https://www.ncbi.nlm.nih.gov/pubmed/24551203
http://dx.doi.org/10.1371/journal.pone.0088983

Ejemplares similares