Inverted terminal repeats of adeno-associated virus decrease random integration of a gene targeting fragment in Saccharomyces cerevisiae

BACKGROUND: Homologous recombination mediated gene targeting is still too inefficient to be applied extensively in genomics and gene therapy. Although sequence-specific nucleases could greatly stimulate gene targeting efficiency, the off-target cleavage sites of these nucleases highlighted the risk...

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Detalles Bibliográficos
Autores principales: Galli, Alvaro, Cervelli, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925961/
https://www.ncbi.nlm.nih.gov/pubmed/24521444
http://dx.doi.org/10.1186/1471-2199-15-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925961/
https://www.ncbi.nlm.nih.gov/pubmed/24521444
http://dx.doi.org/10.1186/1471-2199-15-5

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