Identification of Levothyroxine Antichagasic Activity through Computer-Aided Drug Repurposing

Cruzipain (Cz) is the major cysteine protease of the protozoan Trypanosoma cruzi, etiological agent of Chagas disease. A conformation-independent classifier capable of identifying Cz inhibitors was derived from a 163-compound dataset and later applied in a virtual screening campaign on the DrugBank...

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Detalles Bibliográficos
Autores principales: Bellera, Carolina L., Balcazar, Darío E., Alberca, Lucas, Labriola, Carlos A., Talevi, Alan, Carrillo, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926237/
https://www.ncbi.nlm.nih.gov/pubmed/24592161
http://dx.doi.org/10.1155/2014/279618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926237/
https://www.ncbi.nlm.nih.gov/pubmed/24592161
http://dx.doi.org/10.1155/2014/279618

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