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Identification of Levothyroxine Antichagasic Activity through Computer-Aided Drug Repurposing

Cruzipain (Cz) is the major cysteine protease of the protozoan Trypanosoma cruzi, etiological agent of Chagas disease. A conformation-independent classifier capable of identifying Cz inhibitors was derived from a 163-compound dataset and later applied in a virtual screening campaign on the DrugBank...

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Detalles Bibliográficos
Autores principales:	Bellera, Carolina L., Balcazar, Darío E., Alberca, Lucas, Labriola, Carlos A., Talevi, Alan, Carrillo, Carolina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926237/ https://www.ncbi.nlm.nih.gov/pubmed/24592161 http://dx.doi.org/10.1155/2014/279618

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