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Protection of palmitic acid-mediated lipotoxicity by arachidonic acid via channeling of palmitic acid into triglycerides in C2C12

BACKGROUND: Excessive saturated fatty acids have been considered to be one of major contributing factors for the dysfunction of skeletal muscle cells as well as pancreatic beta cells, leading to the pathogenesis of type 2 diabetes. RESULTS: PA induced cell death in a dose dependent manner up to 1.5 ...

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Detalles Bibliográficos
Autores principales: Cheon, Hyae Gyeong, Cho, Young Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926261/
https://www.ncbi.nlm.nih.gov/pubmed/24521082
http://dx.doi.org/10.1186/1423-0127-21-13