Geldanamycin-mediated inhibition of heat shock protein 90 partially activates dendritic cells, but interferes with their full maturation, accompanied by impaired upregulation of RelB

BACKGROUND: The chaperon heat shock protein 90 (HSP90) constitutes an important target for anti-tumor therapy due to its essential role in the stabilization of oncogenes. However, HSP90 is ubiquitously active to orchestrate protein turnover, chemotherapeutics that target HSP90 may affect immune cell...

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Detalles Bibliográficos
Autores principales: Trojandt, Stefanie, Reske-Kunz, Angelika B, Bros, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926270/
https://www.ncbi.nlm.nih.gov/pubmed/24524692
http://dx.doi.org/10.1186/1756-9966-33-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926270/
https://www.ncbi.nlm.nih.gov/pubmed/24524692
http://dx.doi.org/10.1186/1756-9966-33-16

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