Loop Interactions and Dynamics Tune the Enzymatic Activity of the Human Histone Deacetylase 8

[Image: see text] The human histone deacetylase 8 (HDAC8) is a key hydrolase in gene regulation and has been identified as a drug target for the treatment of several cancers. Previously the HDAC8 enzyme has been extensively studied using biochemical techniques, X-ray crystallography, and computation...

Descripción completa

Detalles Bibliográficos
Autores principales: Kunze, Micha B. A., Wright, David W., Werbeck, Nicolas D., Kirkpatrick, John, Coveney, Peter V., Hansen, D. Flemming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926704/
https://www.ncbi.nlm.nih.gov/pubmed/24171457
http://dx.doi.org/10.1021/ja408184x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926704/
https://www.ncbi.nlm.nih.gov/pubmed/24171457
http://dx.doi.org/10.1021/ja408184x

Ejemplares similares