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Loop Interactions and Dynamics Tune the Enzymatic Activity of the Human Histone Deacetylase 8
[Image: see text] The human histone deacetylase 8 (HDAC8) is a key hydrolase in gene regulation and has been identified as a drug target for the treatment of several cancers. Previously the HDAC8 enzyme has been extensively studied using biochemical techniques, X-ray crystallography, and computation...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926704/ https://www.ncbi.nlm.nih.gov/pubmed/24171457 http://dx.doi.org/10.1021/ja408184x |