A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis

Hedgehog (Hh) signaling is largely suppressed in the normal differentiated tissues of the adult but activated in many cancers. The Hh pathway can either be activated by the expression of Hh ligands, or by mutations that cause constitutive, ligand-independent signaling. Colorectal cancer cells freque...

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Detalles Bibliográficos
Autores principales: Chung, Jon H., Bunz, Fred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926820/
https://www.ncbi.nlm.nih.gov/pubmed/24368541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926820/
https://www.ncbi.nlm.nih.gov/pubmed/24368541

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