Cargando…

Impaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5

Kinesin motor proteins exert essential cellular functions in all eukaryotes. They control mitosis, migration and intracellular transport through interaction with microtubules. Small molecule inhibitors of the mitotic kinesin KiF11/Eg5 are a promising new class of anti-neoplastic agents currently eva...

Descripción completa

Detalles Bibliográficos
Autores principales:	Exertier, Prisca, Javerzat, Sophie, Wang, Baigang, Franco, Mélanie, Herbert, John, Platonova, Natalia, Winandy, Marie, Pujol, Nadège, Nivelles, Olivier, Ormenese, Sandra, Godard, Virginie, Becker, Jürgen, Bicknell, Roy, Pineau, Raphael, Wilting, Jörg, Bikfalvi, Andreas, Hagedorn, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2013
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926828/ https://www.ncbi.nlm.nih.gov/pubmed/24327603

Ejemplares similares

Non‐canonical functions of the mitotic kinesin Eg5
por: Liu, Min, et al.
Publicado: (2018)

Correlating Global Gene Regulation to Angiogenesis in the Developing Chick Extra-Embryonic Vascular System
por: Javerzat, Sophie, et al.
Publicado: (2009)

Correction: Correlating Global Gene Regulation to Angiogenesis in the Developing Chick Extra-Embryonic Vascular System
por: Javerzat, Sophie, et al.
Publicado: (2010)

Probing Spindle Assembly Mechanisms with Monastrol, a Small Molecule Inhibitor of the Mitotic Kinesin, Eg5
por: Kapoor, Tarun M., et al.
Publicado: (2000)

The Kinesin-Related Protein, Hset, Opposes the Activity of Eg5 and Cross-Links Microtubules in the Mammalian Mitotic Spindle
por: Mountain, Vicki, et al.
Publicado: (1999)

Computational fragment-based drug design to explore the hydrophobic subpocket of the mitotic kinesin Eg5 allosteric binding site
por: Oguievetskaia, Ksenia, et al.
Publicado: (2010)

3D-QSAR Studies of Dihydropyrazole and Dihydropyrrole Derivatives as Inhibitors of Human Mitotic Kinesin Eg5 Based on Molecular Docking
por: Luo, Xingyan, et al.
Publicado: (2012)

Kinesin-14 HSET may not oppose kinesin-5 Eg5 activity in RPE-1 cells
por: Carlier-Grynkorn, Frederique, et al.
Publicado: (2022)

Kinesin molecular motor Eg5 functions during polypeptide synthesis
por: Bartoli, Kristen M., et al.
Publicado: (2011)

HSP70 regulates Eg5 distribution within the mitotic spindle and modulates the cytotoxicity of Eg5 inhibitors
por: Fang, Chieh-Ting, et al.
Publicado: (2020)

Double Duty: Mitotic Kinesins and Their Post-Mitotic Functions in Neurons
por: Joseph, Nadine F., et al.
Publicado: (2021)

Activation of mitotic kinesin by microtubule bundling
por: Tomishige, Michio
Publicado: (2008)

Microtubule organization by the antagonistic mitotic motors kinesin-5 and kinesin-14
por: Hentrich, Christian, et al.
Publicado: (2010)

Kinesin Eg5 Targeting Inhibitors as a New Strategy for Gastric Adenocarcinoma Treatment
por: Marconi, Guya Diletta, et al.
Publicado: (2019)

Kinesin-5 Eg5 is essential for spindle assembly and chromosome alignment of mouse spermatocytes
por: She, Zhen-Yu, et al.
Publicado: (2020)

Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development
por: Yu, Wen-Xin, et al.
Publicado: (2022)

The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles
por: Miyamoto, David T., et al.
Publicado: (2004)

Using a comprehensive approach to investigate the interaction between Kinesin-5/Eg5 and the microtubule
por: Guo, Wenhan, et al.
Publicado: (2022)

TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle
por: Ma, Nan, et al.
Publicado: (2011)

Kinesin-related proteins required for assembly of the mitotic spindle
Publicado: (1992)

Mad2 inhibits the mitotic kinesin MKlp2
por: Lee, Sang Hyun, et al.
Publicado: (2010)

The bipolar assembly domain of the mitotic motor kinesin-5
por: Acar, Seyda, et al.
Publicado: (2013)

Lamin B Counteracts the Kinesin Eg5 to Restrain Spindle Pole Separation during Spindle Assembly
por: Goodman, Benjamin, et al.
Publicado: (2010)

Nuclear Eg5 (kinesin spindle protein) expression predicts docetaxel response and prostate cancer aggressiveness
por: Wissing, Michel D., et al.
Publicado: (2014)

Kinesin-5/Eg5 is important for transport of CARTS from the trans-Golgi network to the cell surface
por: Wakana, Yuichi, et al.
Publicado: (2013)

Eg5 inhibitor YL001 induces mitotic arrest and inhibits tumor proliferation
por: Wang, Yufei, et al.
Publicado: (2017)

Structural and Thermodynamic Basis of the Enhanced Interaction between Kinesin Spindle Protein Eg5 and STLC-type Inhibitors
por: Yokoyama, Hideshi, et al.
Publicado: (2018)

Mitotic Centromere–associated Kinesin Is Important for Anaphase Chromosome Segregation
por: Maney, Todd, et al.
Publicado: (1998)

Negative Modulation of the Angiogenic Cascade Induced by Allosteric Kinesin Eg5 Inhibitors in a Gastric Adenocarcinoma In Vitro Model
por: Ricci, Alessia, et al.
Publicado: (2022)

The Multiple Roles of EG-VEGF/PROK1 in Normal and Pathological Placental Angiogenesis
por: Alfaidy, Nadia, et al.
Publicado: (2014)

Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers
por: Scholey, Jessica E, et al.
Publicado: (2014)

Mitotic kinesins in action: diffusive searching, directional switching, and ensemble coordination
por: Gicking, Allison M., et al.
Publicado: (2018)

The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry
por: Atherton, Joseph, et al.
Publicado: (2017)

Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14
por: Benoit, Matthieu P.M.H., et al.
Publicado: (2021)

Identification and partial characterization of mitotic centromere- associated kinesin, a kinesin-related protein that associates with centromeres during mitosis
Publicado: (1995)

The Expanded Kinesin-13 Repertoire of Trypanosomes Contains Only One Mitotic Kinesin Indicating Multiple Extra-Nuclear Roles
por: Wickstead, Bill, et al.
Publicado: (2010)

pEg7, a New Xenopus Protein Required for Mitotic Chromosome Condensation in Egg Extracts
por: Cubizolles, Fabien, et al.
Publicado: (1998)

Poleward Transport of TPX2 in the Mammalian Mitotic Spindle Requires Dynein, Eg5, and Microtubule Flux
por: Ma, Nan, et al.
Publicado: (2010)

Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression
por: Liu, Yang, et al.
Publicado: (2017)

FBXW7/hCDC4 controls glioma cell proliferation in vitro and is a prognostic marker for survival in glioblastoma patients
por: Hagedorn, Martin, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_if3uob4a1fm0ajq3f9aindc0cu