Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis

Mutations in the NF2 gene cause Neurofibromatosis Type 2 (NF2), a disorder characterized by the development of schwannomas, meningiomas and ependymomas in the nervous system. Merlin, a tumor suppressor encoded by the NF2 gene, modulates activity of many essential signaling pathways. Yet despite incr...

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Detalles Bibliográficos
Autores principales: Petrilli, Alejandra M., Bott, Marga, Fernández-Valle, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926832/
https://www.ncbi.nlm.nih.gov/pubmed/24259290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926832/
https://www.ncbi.nlm.nih.gov/pubmed/24259290

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