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PARP inhibitors are not all equal
To many investigators PARP1 is simply a substrate for caspase 3, and whose cleavage is thought indicative of apoptosis. However, in reality PARP1 plays a major role in the biology of the cell cycle and DNA repair.(1)(,)(2) PARP1 binds to damaged DNA where it becomes enzymatically activated and ADP r...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926879/ https://www.ncbi.nlm.nih.gov/pubmed/24025256 http://dx.doi.org/10.4161/cbt.26160 |