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CDK phosphorylation of SLD-2 is required for replication initiation and germline development in C. elegans

Cyclin-dependent kinase (CDK) plays a vital role in proliferation control across eukaryotes. Despite this, how CDK mediates cell cycle and developmental transitions in metazoa is poorly understood. In this paper, we identify orthologues of Sld2, a CDK target that is important for DNA replication in...

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Detalles Bibliográficos
Autores principales: Gaggioli, Vincent, Zeiser, Eva, Rivers, David, Bradshaw, Charles R., Ahringer, Julie, Zegerman, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926958/
https://www.ncbi.nlm.nih.gov/pubmed/24535824
http://dx.doi.org/10.1083/jcb.201310083