TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation

TNF activates three distinct intracellular signaling cascades leading to cell survival, caspase-8–mediated apoptosis, or receptor interacting protein kinase 3 (RIPK3)–dependent necrosis, also called necroptosis. Depending on the cellular context, one of these pathways is activated upon TNF challenge...

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Detalles Bibliográficos
Autores principales: Morioka, Sho, Broglie, Peter, Omori, Emily, Ikeda, Yuka, Takaesu, Giichi, Matsumoto, Kunihiro, Ninomiya-Tsuji, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926964/
https://www.ncbi.nlm.nih.gov/pubmed/24535827
http://dx.doi.org/10.1083/jcb.201305070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926964/
https://www.ncbi.nlm.nih.gov/pubmed/24535827
http://dx.doi.org/10.1083/jcb.201305070

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